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Applications of finite fields to dynamical systems and reverse engineering problems
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Proceedings of the 2004 ACM symposium on Applied computing table of contents
Nicosia, Cyprus
SESSION: Bioinformatics (BIO) table of contents
Pages: 191 - 196  
Year of Publication: 2004
ISBN:1-58113-812-1
Authors
María A. Aviñó  University of Puerto Rico at Cayey Cayey, PR
Edward Green  Virginia Tech, Blacksburg, VA
Oscar Moreno  University of Puerto Rico at Rio Piedras, Rio Piedras, PR
Sponsor
SIGAPP: ACM Special Interest Group on Applied Computing
Publisher
ACM  New York, NY, USA
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ABSTRACT

We present a mathematical model: dynamical systems over finite sets (DSF), and we show that Boolean and discrete genetic models are special cases of DFS, [1, 4, 10].In this paper, we prove that a function defined over finite sets with different number of elements can be represented as a polynomial function over a finite field. Given the data of a function defined over different finite sets, we describe an algorithm to obtain all the polynomial functions associated to this data. As a consequence, all the functions defined in a regulatory network can be represented as a polynomial function in one variable or in several variables over a finite field. We apply these results to study the reverse engineering problem.


REFERENCES

Note: OCR errors may be found in this Reference List extracted from the full text article. ACM has opted to expose the complete List rather than only correct and linked references.

 
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Edward. Green, On polynomial solutions to reverse engineering problems. to appear.
 
3
E. L. Green, M. Leamer, and A. Li, Polynomial models of times series over (Z/p)n, to appear.
 
4
T.E. Ideker, V. Thorsson, and R.M. Karp. Discovery of Regulatory Interactions Through Perturbation: Inference and Experimental Design, Pacific Symposium on Biocomputing 5:302--313 (2000).
 
5
H. de Jong, Modeling and Simulation of Genetic Regulatory Systems: A Literature Review INRIA, No. 4032, 2002.
 
6
R. Laubenbacher, J. Shah, and B. Stigler, Simulation of polynomial systems. To appear in Simulation in the Health and Medical Sciences, Society for Modeling and Simulation International, San Diego, CA, 2003.
 
7
 
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O. Moreno, D. Bollman, and M. Aviño-Diaz, Finite Dynamical Systems, Linear Automata, and Finite Fields, Conference Proceedings, WSEAS Transactions, (2002).
 
9
H. Otiz-Zuzuaga, M. Aviño-Diaz, C. Corrada, R. Laubenbacher, S. Peña de Ortiz, and O. Moreno, Applications of finite fields to the study of microarray expression data preprint(2003).
 
10
R. Somogy and C. Sniegoski, Modeling the complexity of genetic networks: understanding multigenic and pleiotropic regulation. Complexity (1): 45--63, 1996.
 
11
R. Thomas, Regulatory networks seen as asynchronous automata: A logical description. J. Theor. Biol. 153, 123, 1991.
 
12
R. Thomas, Laws for the dynamics of regulatory networks. Int. J. Dev. Biol. 42, 479485, 1998.
 
13
R. Thomas, and R. dAri, Biological Feedback, CRC Press, Boca Raton, FL,1990.
 
14
R. Thomas, A.-M. Gathoye, and L. Lambert A complex control circuit: Regulation of immunity in temperate bacteriophages. Eur. J. Biochem. 71, 211227, 1976.
 
15
R. Thomas, D. Thieffry, and M. Kaufman, Dynamical behaviour of biological regulatory networks: I. Biological rool of feedback loops and practical use of the concept of the loop-characteristic state. Bull. Math. Biol. 57(2), 247 276, 1995.
 
16
R. Thomas, and M. Kaufman, Multistationarity, the basis of cell differentiation and memory: I. Structural conditions of multistationarity and other nontrivial behavior. Chaos 11(1), 170179, 2001.

Collaborative Colleagues:
María A. Aviñó: colleagues
Edward Green: colleagues
Oscar Moreno: colleagues