The genomics of a signaling pathway: a KDD Cup challenge task

ABSTRACT

This article describes Task 2 of the KDD Cup 2002 datamining competition. The task involved predicting whether deletions of individual genes in a yeast genome would affect a particular signaling pathway in the cell. With its rich data sources and abundance of missing information, the task is representative of data mining problems in genomics and proved to be quite challenging.

REFERENCES

• 1: P. 0. Brown and D. Botstein. Exploring the new world of the genome with DNA microarrays. Nature Genetics Supplement, 21:33--37, 1999.
• 2: E. Winzeler and et al. Functional characterization of the Saccharomyces cerevisiae genome by gene deletion and parallel analysis. Science, 285:901--906, 1999.
• 3: G. Yao. Understanding the Ah Receptor Regulatory Network. PhD thesis, McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, 2002.

INDEX TERMS

Keywords:
data mining competition, gene regulation, genomics