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Medical informatics: a personal view of sowing the seeds
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Source History of Medical Informatics archive
Proceedings of ACM conference on History of medical informatics table of contents
Bethesda, Maryland, United States
Pages: 31 - 41  
Year of Publication: 1987
ISBN:0-89791-248-9
Author
R. S. Ledley  Georgetown University Medical Center, 3900 Reservoir Rd., N.W., Washington, D.C.
Sponsor
ACM: Association for Computing Machinery
Publisher
ACM  New York, NY, USA
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REFERENCES

Note: OCR errors may be found in this Reference List extracted from the full text article. ACM has opted to expose the complete List rather than only correct and linked references.

 
1
Ledley RS, Lusted LB: Reasoning foundation of medical diagnosis, Science 130(3366) :9-21, 1959.
 
2
Ledley RS, Luessenhop AJ: "Report on the initial use of the ACTA Scanner," Society of Neurological Surgeons, 1974. Ledley RS, Sohellinger D, DiGhiro G: New transverse axial tomographic unit: introduction and initial results, lOth Symp. Neuroradiologicum, Punta Del Este, Uruguay, 1974. Kiker WE, Ledley RS: The ACTA Scanner, Proc. SPIE, 47:40-43, Kansas City, 1974. Ledley RS, DiChiro G, Luessenhop AJ, Twigs HL: Computerized transaxial x-ray tomography of the human body, Science 186:207-212, 1974; reprinted in Sondak V, et al, "Computers and Medicine," 155-160, Dedham, 1979
 
3
Rotolo LS, Wilson JB, Ginsberg MD, Ledley RS: Digital computer picture processor, Proc. 16th ACEMB, 14-15, 1963. Ledley RS, Ruddle F, Migeon B: Computer analysis of chromosomes, Proc. 16th ACEMB, 1963. Ledley RS: High-speed automatic analysis of biomedical pictures, Science 146:216-223, 1964.
 
4
Orcutt BC, George DG, Dayhoff MO: Protein and nucleic acid sequence database system, Ann. Review Biophys. Bioeng. 12:419-441, 1983. Barker WG, Hunt LT, Orcutt BC, George DG, Yeh LS, Chen HR, Blomquist MC, Johnson GC, Seibel-Ross EI: Protein and nucleic acid sequence databases of the protein identification resource, O'Brien SJ, ed., in "Genetic maps 1984,3 522-553, Cold Spring Harbor Lab, 1984. Barker WC, Hunt LT, George DG, Orcutt BC: A resource for protein identification, in "The role of data in " Glaeser PS, ed , 127-133, scientific progress, Elsevier Science Pub., 1985 Reprinted in CODATA Bulletin 56:28-34, Nov. 1984.
 
5
Dayhoff MO, Ledley RS: The use of computers in protein biochemistry, Digest 15th ACEMB, 34, 1962. Dayhoff MO, Ledley RS: Comprotein: A computer program to aid primary protein structure determination, Proc. Fall Joint Co__~uter Conf., 262-274, 1962.
 
6
Barker WC, Hunt LT, George DG, Ledley RS: The protein identification resource, Federation Proc. 44(6):1925, 1985 (Abstract).
 
7
Margaret Oakley Dayhoff 1925-1983, Bull. of Math. Biol. 46(4):467-472, 1984.
 
8
Ledley RS: "The Use of Computers in Biology and Medicine," McGraw-Hill, NY, 1965.
 
9
Ledley RS: "Digital Computer and Control Engineering, "McGraw-Hill, NY, 1960
 
10
Ledley RS: Programming and Utilizing Digital Computers," McGraw-Hill, NY, 1962.
 
11
Ledley RS, Lusted LB: The use of electronic computers to aid in medical diagnosis, Proc. IRE 47( 11):1970-1977, 1959. Ledley RS, Lusted LB: The use of electronic computers in medical data processing, IRE Trans. Med. Elect. ME-7: 31-47, 1960. Lusted LB, Ledley RS: Mathematical models in medical diagnosis, J. Med. Ed. 35(3):214-222, 1960. Ledley RS, Lusted LB: Computers in medical data processing, Operations Res. 8(3) :299-310, 1960. Ledley RS: Using electronic computers in medical diagnosis, IRE Trans. Med. Elect. ME-7:P74-280, 1960. Lusted LB, Ledley RS: Medical applications of electronic computers, Proc. 3rd Intl. Conf. Med. Electronics, 10-14, 1960. Ledley RS, Lusted LB: The dynamic treatment-reevaluation cycle in medical diagnosis, Digest 1961 Intl. Conf. Med. Elect., 1961. Ledley RS, Oestreieh AE, Lusted LB: Conditional probabilities in medical diagnosis, Digest 15th ACEMB, 2, 1962.
 
12
Ledley RS: "Many-component propositional two-valued logic and general propositional constraints," National Bureau of Standards, 1954. Ledley RS: "The absolute simplest form in digital circuit design," National Bureau of Standards, 1954. Ledley RS: "A digitalization, systemization and formulation of the theory and methods of the propositional calculus," Nat. Bur. Stand., Report No. 3363, Feb. 1, 1954.
 
13
Ledley RS: Digital computational methods in symbolic logic, with examples in biochemistry, Proc. Nat. Acad. Sol. 4:498-511, 1955. Ledley RS: Boolean matrix equations in digital circuit design, IRE Trans. Elect. comRuters EC-8: 131 - 139, 1959.
 
14
Ledley RS: Boolean matrices applied to sequential circuit theory and threshold logics, in "Switching Circuit Theory and Logical Design," 266-291, AIEE, NY, 1961.
 
15
Ledley RS: Digital computational methods in symbolic logic, with examples in biochemistry, Proc. Nat. Acad. Sci. 4:498-511, 1955.
 
16
Ledley RS: Mathematical foundations and computational methods for a digital logic machine, J. Operations Res. Soc. Amer. 2:249-274, 1954. Ledley RS, Rotolo LS: A heuristic concept and automatic computer aid for operations simulation, Naval Res. Logistics Quarterly 9:231-244, 1962.
 
17
Huang HK, Ledley RS: Three dimensional image reconstruction from in vivo consecutive transverse axial sections, Comp_~ Biol. Med. 5:165-170, 1975. Ledley RS, Huang HK: Three-dimensional reconstruction of consecutive transverse axial images from the ACTA-Scanner, Proc. ACEMB 1975.
 
18
Kiker WE, Hinz TW, Ledley RS: Variation of ACTA Scanner numbers with the physical properties of the scanned material, Med. Phys. 3:42-44, 1976. Huang HK, Ledley RS: Correlating the CT numbers of body constituents with their mass densities and calcium concentrations, Proc. SPIE 96, 288-293, Palos Verdes Estates, CA, 1976. Huang HK, Wu SC, Ledley RS: Evaluation of the mass density distribution of the human body in vivo- theoretical aspect, Proc. 29th ACEMB, 62, Boston, 1976. Bradley JG, Huang HK, Ledley RS, Ray RD: Correlations between ACTA numbers of bone and its calcium levels, Proc. 29th ACEMB, 108, Boston, 1976. Huang HK, Rotolo LS: Evaluation of mass densities of body tissues and calcium concentrations of bone by computerized tomographic techniques, Biophysical J. 17;247a, 1977. Huang HK, Wu SC: The evaluation of mass densities of the human body in vivo from CT scans, Comp. in Biol. Med. 6:337-343, 1976.
 
19
Ledley RS, Wu SC, Granke RC: Isodose distributions of multiple beams radiation for body inhomogeneities: An application of the ACTA-Scanner in radiation therapy, Abstr. of ~.iv en at 61 st annual meetin~ of Radiological Soc~--N. Am. 1975. Wu SC, Ledley R~ Application of the ACTA-Scanner in the radiation (Co-60) therapy for body inhomogeneities, Proc. 29th ACEMB_z 436, Boston, 1976. Ledley RS, Rotolo LS, Joseloff SH: Application of CT scans in the radiation (Co-60) therapy for body inhomogeneities, Biophysical J. 17:246a, 1977. Scheer AC, Ledley RS, Huang HK: Radiation therapy treatment planning with computerized tomography, Biophysical; J. 21:129a, 1978.
 
20
Hinz TW, Kiker WE, Bransford CL, Ledley RS: Patient dose distributions during transverse axial scanning tomography, Med. Phys___~. 1:115, 1974. Huang HK: "Experiment on the transverse axial scan of a specially designed phantom by using the ACTA-Scanner," NBR Report No. 741115-ACTA, 1974. DiChiro G, Axelbaum SP, Schellinger D, Twigg HL, Ledley RS: Computerized axial tomography in syringomyelia, New Eng. J__a' Mad. 292(1);13-16, 1975. Schellinger D, DiChiro G, Axelbaum SP, Twigg HL, Ledley RS: Early clinical experience with the ACTA Scanner, Radiology 114:257-261, 1975.
 
21
Ledley RS, Wilson JB: Concept analysis by syntax processing, Proc. Amer. Documentation Inst. 1:1-8, 1964. Ledley RS, Rotolo LS, Golab TJ, Jacobsen JD, Ginsberg MD, Wilson JB: FIDAC: Film input to digital automatic computer and associated syntax directed pattern recognition programming system, in "Optical and Electro-optical in formation Processing Technology," MIT Press, Cambridge, 591-613, 1965.
 
22
Ledley RS, Kulkarni YG, Rotolo LS, Golab TJ, Wilson JB: TEXAC: A special purpose picture processing texture analysis computer, Proc. 15th IEEE Comp. Soc. Intl. Conf., 66-71, Wash, DC, 1977 (Prize paper).
 
23
Ledley RS, et al.: "Photomicrographic analysis of central nervous system (Progress Report)," NBR Report No. 65081/04472, 1965 Ledley RS: Analysis of the dendrites of a neuron photographed in a single section, Bi~s. Soc. Abstr., 129, 1966. Belson M, Dudley AW, Ledley RS: Automatic computer measurements of neurons, Pattern Recognition 1: 119-128, 1968.
 
24
Ledley RS: Practical problems in the use of computers in medical diagnosis, Proc. of the iEEE 57:1900-1918, 1969. Ledley RS, Rotolo LS: Application of pattern recognition to biomedical problems, in "Automatic Interpretation and Classification of Images," Grasselli A, ed., 323-362, Academic Press, NY, 1969. Ledley RS: Use of computers in biomedical pattern recognition, in "Advances in Computers" 10:217-252, Academic Press, NY, 1970.
25
 
26
Ledley RS: Digital difference radiology, "MEDINFO 83," Proc. ~th World Conf. on Medical Informatics, Van Bemmel JH, et al, eds., 355-358, Elsevier, 1983. Ledley RS: "Digital fluorographic method and system," US Patent #4,450,478, May 22, 1984.
 
27
GUMC introduces revolutionary automatic genetic analyzer, Georgetown Univ. Med. Center Report 9(3), {3}, Winter 1984. Ledley RS, Gersten DM, Zapolski EJ, Golab TJ, Rotolo LS: Automating the DNA hybridization, MIDCON/85, Chic ago, IL, 1985.
 
28
Ledley RS, Lubs HA: Metachrome instrument, Frontiers of Engineering and Computing in Health Care, 7th Ann. Conf. IEEE/EMBS, 1985, 986-990. Buas M, Golab TJ, Ledley RS: Automated chromosome analysis, MEDINFO 86.
 
29
Cheng GC, Kwok HM: Automatic ray tracing of the optical system of the eye, Proc. 18th ACEMB, 46, 1965. Ledley RS, Cheng GC, Ludlum WM: Computer ray tracing of the optical system of the schematic eye, Nature 211:930-932, 1966.
 
30
Ledley RS: The relation of occlusal surfaces to the stability of artificial dentures, J. Amer. Dent. Assoc. 48:508-526, 1954. Ledley RS: Mastication and denture stability, J. Amer. Dent. Assoc. 50:241-242, 1955. Ledley RS: A new method of determining the functional forces applied to prosthetic appliances, J. Prosthetic Dent. 5: 546-562, 1955.
 
31
Computer Development (SEAC and DYSEAC) at the National Bureau of Standards, Washington, D.C., NBS Circular 551, Jan. 25, 1955.
 
32
Ledley RS: "The use of computers in biology and medicine," Nat. Aead. Sei., Nat. Res. Council, 1960. Ledley RS, Lusted LB: Biomedical electronics : potentialities and problems, Science 135(3499):198-20~, 1962.