Feedback-control modeling for cellualr response mechanisms based on a gene regulatory networks under radiotherapy

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Feedback-control modeling for cellualr response mechanisms based on a gene regulatory networks under radiotherapy

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ACM/SIGEVO Summit on Genetic and Evolutionary Computation archive
Proceedings of the first ACM/SIGEVO Summit on Genetic and Evolutionary Computation table of contents

Shanghai, China

POSTER SESSION: Poster sessions table of contents

Pages 933-936

Year of Publication: 2009

ISBN:978-1-60558-326-6

Authors

Jinpeng Qi	College of Information Sciences and Technology, Donghua University, Shanghai, China
Shihuang Shao	College of Information Sciences and Technology, Donghua University, shanghai, China
Zhihai Rong	College of Information Sciences and Technology, Donghua University, shanghai, China

Sponsors

SIGEVO: ACM Special Interest Group on Genetic and Evolutionary Computation
ACM: Association for Computing Machinery

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ACM New York, NY, USA

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ABSTRACT

In response to genome stresses, cell can trigger the self-defensive mechanisms by regulating the vital genes and their complicated signal pathways. To illustrate the celluar response in fighting against DNA damage under radiotherapy, a feedback-control model of P53 stress response networks is proposed at single cell level. The kinetics of Double Strand Breaks(DSBs) generation and repair, ARF and ATM activation, P53-MDM2 regulation, toxins degradation, as well as feedback-control to ion radiation (IR) dose are presented.

REFERENCES

Note: OCR errors may be found in this Reference List extracted from the full text article. ACM has opted to expose the complete List rather than only correct and linked references.

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