Heterogeneous data fusion for alzheimer's disease study

ABSTRACT

Effective diagnosis of Alzheimer's disease (AD) is of primary importance in biomedical research. Recent studies have demonstrated that neuroimaging parameters are sensitive and consistent measures of AD. In addition, genetic and demographic information have also been successfully used for detecting the onset and progression of AD. The research so far has mainly focused on studying one type of data source only. It is expected that the integration of heterogeneous data (neuroimages, demographic, and genetic measures) will improve the prediction accuracy and enhance knowledge discovery from the data, such as the detection of biomarkers. In this paper, we propose to integrate heterogeneous data for AD prediction based on a kernel method. We further extend the kernel framework for selecting features (biomarkers) from heterogeneous data sources. The proposed method is applied to a collection of MRI data from 59 normal healthy controls and 59 AD patients. The MRI data are pre-processed using tensor factorization. In this study, we treat the complementary voxel-based data and region of interest (ROI) data from MRI as two data sources, and attempt to integrate the complementary information by the proposed method. Experimental results show that the integration of multiple data sources leads to a considerable improvement in the prediction accuracy. Results also show that the proposed algorithm identifies biomarkers that play more significant roles than others in AD diagnosis.

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INDEX TERMS

Primary Classification:
  H. Information Systems
  H.2 DATABASE MANAGEMENT
      H.2.8 Database applications
          Subjects: Data mining

Additional Classification:
  J. Computer Applications
  J.3 LIFE AND MEDICAL SCIENCES
      Subjects: Medical information systems; Health

General Terms:
Algorithms

Keywords:
biomarker detection, heterogeneous data source fusion, multiple kernel learning, neuroimaging, tensor factorization