| Reconstructing networks using co-temporal functions |
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ACM Southeast Regional Conference
archive
Proceedings of the 44th annual Southeast regional conference
table of contents
Melbourne, Florida
SESSION: Bioinformatics and ethics
table of contents
Pages: 417 - 422
Year of Publication: 2006
ISBN:1-59593-315-8
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Authors
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Edward E. Allen
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Wake Forest University, Winston-Salem, North Carolina
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Anthony Pecorella
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Wake Forest University, Winston-Salem, North Carolina
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Jacquelyn S. Fetrow
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Wake Forest University, Winston-Salem, North Carolina
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David J. John
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Wake Forest University, Winston-Salem, North Carolina
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William Turkett
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Wake Forest University, Winston-Salem, North Carolina
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Downloads (6 Weeks): 2, Downloads (12 Months): 15, Citation Count: 1
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ABSTRACT
Reconstructing networks from time series data is a difficult inverse problem. We apply two methods to this problem using co-temporal functions. Co-temporal functions capture mathematical invariants over time series data. Two modeling techniques for co-temporal networks, one based on algebraic techniques and the other on Bayesian inference, are compared and contrasted on simulated biological network data.
REFERENCES
Note: OCR errors may be found in this Reference List extracted from the full text article. ACM has opted to expose the complete List rather than only correct and linked references.
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Probabilistic network library. Intel Corporation Open Source Community, 2004. https://sourceforge.net/projects/openpnl/.
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2
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E. E. Allen, J. S. Fetrow, L. W. Daniel, S. J. Thomas, and D. J. John. Algebraic dependency models of protein signal transduction networks from time-series data. Journal of Theoretical Biology, 238(2):317--330, January 2006. doi:10.1016/j.jtbi.2005.05.010.
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3
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4
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5
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D. Heckerman. A tutorial on learning with Bayesian networks. Technical report, Microsoft Research, 1995. revised 1996.
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6
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D. Husmeier. Sensitivity and specificity of inferring genetic regulatory interactions from microarray experiments with dynamic Bayesian networks. Bioinformatics, 19:2271--2282, 2003.
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7
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8
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9
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R. Laubenbacher and B. Stigler. A computational algebra approach to the reverse engineering of gene regulatory networks. Journal of Theoretical Biology, 229(4):523--537, August 2004. doi:10.1016/j.jbi2004.04.037.
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10
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K. Murphy. The Bayes net toolbox for matlab. Computing Science and Statistics, 33, 2001.
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11
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J. Pearl. Reverend Bayes on inference engines: A distributed hierarchical approach. In D. Waltz, editor, AAAI National Conference on AI, pages 133--136. AAAI Press, August 1982.
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12
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E. Pennisi. How will big pictures emerge from a sea of biological data? Science, 309:94, July 2005.
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13
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K. Sachs, O. Perez, D. Pe'er, D. A. Lauffenburger, and G. P. Nolan. Causal protein-signaling networks derived from multiparameter single-cell data. Science, 308:523--529, April 2005.
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14
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15
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J. Yu, V. A. Smith, P. P. Wang, A. J. Hartemink, and E. D. Jarvis. Using Bayesian network inference algorithms to recover molecular genetic regulatory networks. In International Conference on Systems Biology (ICSB02), December 2002.
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CITED BY
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Edward E. Allen , Liyang Diao , Jacquelyn S. Fetrow , David J. John , Richard F. Loeser , Leslie B. Poole, The shuffle index and evaluation of models of signal transduction pathways, Proceedings of the 45th annual southeast regional conference, March 23-24, 2007, Winston-Salem, North Carolina
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