CELLSIM: A digital simulation language for cell kinetic modelling

ABSTRACT

The field of cell kinetics relates to the movement and proliferation of cells through their generative cycle, and how this cycle is affected by chemotherapy treatment. CELLSIM is a discrete, digital simulation language for modelling this process. It allows testing of assumptions about cell kinetics and chemotherapy. The language is interpretive, with the interpreter written in FORTRAN, and has been implemented on a wide variety of computer systems. The language features dynamic memory allocation, arithmetic string manipulation, and the capability of generating random variates from nine classic probability distributions. It uses vocabulary and conventions familiar to the cell kinetics scientist, and is now utilized by some who never before used computers in their research.

REFERENCES

• 1: Donaghey, C. E. (1975) CELLSIM II User's Manual. Industrial Engineering Department, University of Houston, Houston, Texas 77004.
• 2: Donaghey, C. E., Dewan, P. and Singh, D. (1970) A Beginner's Language For LP. Industrial Engineering. Dec., 17.
• 3: Donaghey, C. E. and Drewinko, B. (1975), A Computer Simulation Program For The Study Of Cellular Growth Kinetics And Its Application To The Analysis Of Human Lymphoma Cells In Vitro. Computers Biomed. Res. 8, 118.
• 4: Donaghey, C. E., Drewinko, B., Barlogie, B. and Stubblefield, E. (1978), Simulated FMF Analysis With CELLSIM. Bio Systems (in press).
• 5: Donaghey, C. E. and Ozkul, O. (1971), A Simplified Computer Language For Statistics. J. Engr. Educ. 61, 359.
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• 7: Ozkul, O. and Donaghey, C. E. (1972), Cell Kinetics Simulation System. Industrial Engineering Department, University of Houston, Houston, Texas 77004.
• 8: Stubblefield, E. (1974), Summer Computer Simulation Conference, 697.
• 9: Stubblefield, E. and Dennis, C. M. (1976), The Simulation Of Thymidine Kinase Enzyme Kinetics In Cultured Cells Using The Computer Language CELLSIM. J. Theoretical Biol. 61, 171.
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INDEX TERMS

Primary Classification:
  I. Computing Methodologies
  I.6 SIMULATION AND MODELING
      I.6.3 Applications

Additional Classification:
  I. Computing Methodologies
  I.6 SIMULATION AND MODELING
      I.6.2 Simulation Languages
      I.6.5 Model Development
          Subjects: Modeling methodologies

  J. Computer Applications
  J.3 LIFE AND MEDICAL SCIENCES

General Terms:
Human Factors, Languages, Performance

Keywords:
Cell kinetics, Chemotherapy, Computer languages, Interpreter, Monte-Carlo, Simulation, Tumor